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Building the Future of C. difficile Research with a Human Infection Model
Clostridioides difficile (C. difficile) remains a major cause of healthcare-associated diarrhoea, with rising antibiotic resistance and frequent relapses making treatment increasingly difficult. While faecal microbiota transplantation has shown promise, the exact mechanisms behind its success remain unclear, highlighting the urgent…
Female-Only Schistosomiasis Infection Model Reveals Surprising Resistance
In this study schistosomiasis research is boosted by developing the first controlled human infection model using female-only Schistosoma mansoni parasites. This innovative approach aims to accelerate vaccine development and deepen our understanding of early immune responses to the disease. Thirteen…
Genetically Attenuated Parasites Ushers In a New Era in Malaria Vaccination
Despite decades of effort, malaria remains a global health challenge, with current vaccines offering only modest and short-lived protection. This clinical trial brings fresh hope by testing a next-generation vaccine strategy using live, genetically attenuated Plasmodium falciparum parasites. In this…
New Hope for Vaccine Development for Hookworm Infection
Hookworm remains a persistent health threat in many parts of the world, with reinfection common despite mass drug treatments. This study offers insights into how the human immune system responds to hookworm, thus providing crucial knowledge for developing an effective…
Latest publications
July 7, 2025
Hensen, A.D.O., et al. How to develop a controlled human infection model for Clostridioides difficile. CMI. 2025;31(3): 373-379.
July 5, 2025
Koopman JPR, Houlder EL, Janse JJ, et al. Safety and infectivity of female cercariae in unexposed, healthy participants: a controlled human Schistosoma mansoni infection study. Lancet eBioMedicine. 2023
July 4, 2025
Lamers OAC, Franke-Fayard BMD, Koopman JPR, et al. Safety and protection by a late-liver-stage attenuated malaria parasite. New England Journal of Medicine. 2024
July 3, 2025
Hoogerwerf, M.A., et al., Protective efficacy of short-term infection with Necator americanus hookworm larvae in healthy volunteers in the Netherlands: a single-centre, placebo-controlled, randomised, controlled, phase 1 trial. Lancet Microbe, 2023. 4(12): p. e1024-e1034.
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